Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.76 |
| ▸ | MEN1 | O00255 | 11/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.74 |
| ▸ | MAPT | P10636 | 7/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | AHR | P35869 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16627429 | 0.87 | MAPT (0.58) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL479877 | 0.86 | DHODH (1.00) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28816740 | 0.86 | DHODH (0.81) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL16616643 | 0.86 | DHODH (0.76) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL16616388 | 0.86 | RAB9A (0.76) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9075528 | 0.85 | MEN1 (1.00) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7281512 | 0.84 | DHODH (0.71) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL479805 | 0.83 | DHODH (0.76) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL13196213 | 0.83 | DHODH (0.66) | DHODHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL16616459 | 0.83 | MEN1 (0.80) | DHODHMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092928-A1 | BENZONAPHTHYRIDINE COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME | 주식회사 진웅산업 | 2018-05-24 | — | — | WO | disclosed |
| EP-3243822-A1 | SELENOPHENE DERIVATIVES AND ORGANIC PHOTOELECTRIC DEVICE, IMAGE SENSOR AND ELECTRONIC DEVICE INCLUDING THE SAME | Samsung Electronics Co., Ltd (KR) | 2017-11-15 | — | — | EP | disclosed |
| US-9006451-B1 | 2-anilinonicotinyl based chalcones useful as potential anticancer agents and process for preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-04-14 | — | — | US | disclosed |
| US-20150099888-A1 | 2-Anilinonicotinyl Based Chalcones Useful As Potential Anticancer Agents and Process for Preparation Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-04-09 | — | — | US | disclosed |
| EP-2694480-B1 | ADAMANTYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| EP-2694480-A1 | ADAMANTYL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-02-12 | — | — | EP | disclosed |
| US-8471027-B2 | Adamantyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8471027-B2 | Adamantyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8471027-B2 | Adamantyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | CHEUNG ADRIAN WAI-HING (US) | 2012-10-11 | — | — | US | disclosed |
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | CHEUNG ADRIAN WAI-HING (US) | 2012-10-11 | — | — | US | disclosed |
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | CHEUNG ADRIAN WAI-HING (US) | 2012-10-11 | — | — | US | disclosed |
| WO-2012136684-A1 | ADAMANTYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-11 | — | — | WO | disclosed |
| US-8163906-B2 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | ROCHE PALO ALTO, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2148862-B1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2012-03-28 | — | — | EP | disclosed |
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |
| US-20080287458-A1 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | ROCHE PALO ALTO LLC | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | MAP3K1, MAP3K6, MAPKAPK2 | DHODH 3183/4885MEN1 3226/4885KMT2A 3602/4885 |
| US-20150099888-A1 | 2-Anilinonicotinyl Based Chalcones Useful As Potential Anticancer Agents and Process for Preparation Thereof | HCCS, WEE2, WEE1 | DHODH 637/4885MEN1 2511/4885KMT2A 2973/4885 |
| US-20080287458-A1 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | MAPK9, MAPK10, MAPK1 | DHODH 434/4885MEN1 4324/4885KMT2A 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.