Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.65 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.65 |
| ▸ | DRD3 | P35462 | 2/20 | 0.65 |
| ▸ | CASR | P41180 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | MLNR | O43193 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.65 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.65 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.65 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | MC3R | P41968 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28414827 | 1.00 | ADRA2C (0.65) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 | |
| SCHEMBL29761425 | 1.00 | ADRA2C (0.65) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 | |
| SCHEMBL1491248 | 1.00 | ADRA2C (0.65) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 | |
| SCHEMBL1491247 | 1.00 | ADRA2C (0.65) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 | |
| SCHEMBL14026866 | 0.85 | ADRA2C (0.53) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 | |
| SCHEMBL6752551 | 0.84 | LMNA (0.56) | LMNAEPHX2GAAMETAP2METAP1 | |
| SCHEMBL28476355 | 0.83 | ADRA2C (0.59) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 | |
| SCHEMBL716961 | 0.83 | ADRA2C (0.65) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 | |
| SCHEMBL1580540 | 0.83 | ADRA2C (0.65) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 | |
| SCHEMBL17053439 | 0.81 | CASR (0.87) | ADRA2CSLC6A2HTR2CSLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406211-B1 | A NEW METHOD FOR THE PREPARATION OF CINACALCET AND NEW INTERMEDIATES THEREOF | MEGAFINE PHARMA P LTD (IN) | 2018-06-27 | — | — | EP | disclosed |
| EP-1990333-A1 | Process for the preparation of cinacalcet hydrochloride | Sandoz AG (CH) | 2008-11-12 | — | — | EP | disclosed |