SCHEMBL8469434

SCHEMBL8469434

C=CC1C(=O)NC(=O)C1C=CCCCCCC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.42
FAAH O00519 2/20 0.39
TRPV1 Q8NER1 1/20 0.39
EPHX2 P34913 1/20 0.38
MGLL Q99685 1/20 0.37
PPARG P37231 2/20 0.37
TYR P14679 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MEN1 O00255 1/20 0.36
CYP3A4 P08684 1/20 0.36
KMT2A Q03164 1/20 0.36
GMNN O75496 1/20 0.35
USP2 O75604 1/20 0.35
LMNA P02545 1/20 0.35
CYP1A2 P05177 1/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
CYP2C9 P11712 1/20 0.35
ALOX15 P16050 1/20 0.35
APEX1 P27695 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8467770 0.85 TSHR (0.38) TSHRFAAHTRPV1EPHX2MGLL
SCHEMBL8467860 0.82 FAAH (0.40) TSHRFAAHTRPV1EPHX2MGLL
SCHEMBL8469166 0.81 FAAH (0.39) TSHRFAAHTRPV1EPHX2MGLL
SCHEMBL8469066 0.79 EPHX2 (0.40) TSHRFAAHTRPV1EPHX2MGLL
SCHEMBL6077561 0.78 EPHX2 (0.39) TSHRFAAHTRPV1EPHX2MGLL
SCHEMBL8468096 0.76 ALDH1A1 (0.36) TSHRFAAHTRPV1EPHX2PPARG
SCHEMBL5545836 0.73 ALDH1A1 (0.41) TSHRFAAHTRPV1EPHX2MGLL
SCHEMBL8205768 0.73 ALDH1A1 (0.41) TSHRFAAHTRPV1EPHX2MGLL
SCHEMBL11606967 0.73 ALDH1A1 (0.41) TSHRFAAHTRPV1EPHX2MGLL
SCHEMBL5617257 0.73 ALDH1A1 (0.41) TSHRFAAHTRPV1EPHX2MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5942470-A OIL SOLUBLE SULFUR CONTAINING PRESSURE AND ANTI-WEAR AGENT, AMINE SALT OF PHOSPHORUS ESTER, SUCCINIMIDE, AND ASHLESS DISPERSANTS ETHYL PETROLEUM ADDITIVES, INC. (US) 1999-08-24 US disclosed
EP-0459656-B1 Lubricant compositions ETHYL PETROLEUM ADDITIVES INC (US) 1995-09-20 EP disclosed
EP-0448207-B1 Lubricant compositions ETHYL PETROLEUM ADDITIVES INC (US) 1993-12-15 EP disclosed
US-5225093-A Metal free ETHYL PETROLEUM ADDITIVES, INC. (US) 1993-07-06 US disclosed
US-5176840-A Succinimide ETHYL PETROLEUM ADDITIVES, INC. (US) 1993-01-05 US disclosed
EP-0459656-A1 Lubricant compositions ETHYL PETROLEUM ADDITIVES, INC. (US) 1991-12-04 EP disclosed
EP-0448207-A1 Lubricant compositions ETHYL PETROLEUM ADDITIVES, INC. (US) 1991-09-25 EP disclosed