Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | HTR6 | P50406 | 8/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8469872 | 0.83 | BRD4 (0.38) | BRD4HTR6PTPN11DRD2HTR1A | |
| SCHEMBL3355608 | 0.81 | PDPK1 (0.42) | BRD4HTR6CTSLPTPN11PDPK1 | |
| SCHEMBL8443973 | 0.79 | SCN9A (0.39) | BRD4HTR6CTSLPTPN11DRD2 | |
| SCHEMBL13505045 | 0.78 | HTR6 (0.45) | BRD4HTR6DRD2HTR1AHTR2A | |
| SCHEMBL13504975 | 0.78 | BRD4 (0.38) | BRD4HTR6PTPN11DRD2HTR1A | |
| SCHEMBL8473892 | 0.78 | HTR6 (0.38) | BRD4HTR6CTSLPTPN11DRD2 | |
| SCHEMBL13504982 | 0.77 | BRD4 (0.36) | BRD4HTR6PTPN11DRD2HTR1A | |
| SCHEMBL3346632 | 0.66 | PDPK1 (0.45) | BRD4HTR6PDPK1 | |
| SCHEMBL13620691 | 0.65 | HTR6 (0.53) | BRD4HTR6PTPN11DRD2HTR1A | |
| SCHEMBL3352661 | 0.64 | PDPK1 (0.43) | BRD4HTR6PTPN11PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |