Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MTTP | P55157 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | APOB | P04114 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8470841 | 0.95 | EPHX2 (0.40) | MAPTTSHRMTTPALDH1A1HDAC6 | |
| SCHEMBL8471802 | 0.81 | ESR1 (0.49) | MTTPALDH1A1HDAC6HPGDKMT2A | |
| SCHEMBL8470752 | 0.81 | ESR1 (0.43) | TSHRMTTPALDH1A1LMNAKDM4E | |
| SCHEMBL8473043 | 0.81 | HDAC6 (0.42) | MAPTALDH1A1HDAC6HPGDKMT2A | |
| SCHEMBL8582518 | 0.80 | ESR1 (0.44) | MTTPALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL8471797 | 0.80 | ESR1 (0.43) | MTTPALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL8474115 | 0.79 | KDM4E (0.51) | TSHRMTTPALDH1A1KDM4EESR1 | |
| SCHEMBL8474739 | 0.79 | PRMT5 (0.40) | MTTPALDH1A1HPGDKMT2ACD274 | |
| SCHEMBL8473518 | 0.79 | MTTP (0.40) | TSHRMTTPALDH1A1LMNAKDM4E | |
| SCHEMBL8473578 | 0.79 | ACACB (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919795-A | ATHEROSCLEROSIS THERAPY | PFIZER INC. (US) | 1999-07-06 | — | — | US | claimed |
| US-5919795-A | ATHEROSCLEROSIS THERAPY | PFIZER INC. (US) | 1999-07-06 | — | — | US | disclosed |