Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974231 | 0.83 | HDAC6 (0.45) | HDAC6GAASMN1; SMN2AKR1C3ALDH1A1 | |
| SCHEMBL8470288 | 0.81 | MAPT (0.42) | HDAC6GAASMN1; SMN2AKR1C3ALDH1A1 | |
| SCHEMBL8470841 | 0.80 | EPHX2 (0.40) | HDAC6GAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8471802 | 0.80 | ESR1 (0.49) | HDAC6GAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8582518 | 0.77 | ESR1 (0.44) | GAASMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL8474108 | 0.76 | MEN1 (0.45) | ALDH1A1KDM4ELMNAKMT2AHPGD | |
| SCHEMBL8474739 | 0.76 | PRMT5 (0.40) | ALDH1A1KMT2AHPGDESR1ESR2 | |
| SCHEMBL8473578 | 0.75 | ACACB (0.47) | — | |
| SCHEMBL8471317 | 0.75 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6962135 | 0.75 | GAA (0.60) | HDAC6GAASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919795-A | ATHEROSCLEROSIS THERAPY | PFIZER INC. (US) | 1999-07-06 | — | — | US | disclosed |