Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491292 | 0.79 | EGFR (0.43) | EGFRALDH1A1HSD17B10CASP1HTT | |
| SCHEMBL31155594 | 0.76 | KDM4E (0.55) | EGFRALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL3481303 | 0.76 | KDM4E (0.55) | EGFRALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL30912753 | 0.75 | EGFR (0.57) | EGFRALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL610225 | 0.75 | EGFR (0.57) | EGFRALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL31391395 | 0.75 | CYP1A2 (0.56) | EGFRALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL12003727 | 0.75 | CYP1A2 (0.56) | EGFRALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL12817931 | 0.73 | EGFR (0.37) | EGFRALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL10764173 | 0.72 | EGFR (0.43) | EGFRKDM4EMAPTATMBRD9 | |
| SCHEMBL8469459 | 0.72 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HTTPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038983-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1997-10-23 | — | — | WO | disclosed |