Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SORD | Q00796 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29743114 | 0.79 | RECQL (0.39) | P4HTMKDM4ESLC6A7P2RX7EGLN2 | |
| SCHEMBL10372621 | 0.74 | SMN1; SMN2 (0.55) | KDM4EALDH1A1 | |
| SCHEMBL4344306 | 0.72 | BCHE (0.43) | P4HTMKDM4EEGLN2ALDH1A1SORD | |
| SCHEMBL18058632 | 0.70 | EGLN2 (0.40) | EGLN2ARALDH1A1TAS2R8LMNA | |
| SCHEMBL5767440 | 0.69 | PIM1 (0.44) | P4HTMKDM4EP2RX7HTR1AOPRM1 | |
| SCHEMBL9822943 | 0.68 | NPC1 (0.45) | KDM4EALDH1A1SORDLMNA | |
| SCHEMBL27481595 | 0.67 | HPGD (0.53) | P4HTMKDM4ESLC6A7OPRM1ALDH1A1 | |
| SCHEMBL19540824 | 0.67 | ADRB1 (0.52) | KDM4EEGLN2ARALDH1A1L3MBTL1 | |
| SCHEMBL5900916 | 0.67 | BCHE (0.52) | KDM4EARALDH1A1TAS2R8LMNA | |
| SCHEMBL5616510 | 0.67 | HTT (0.56) | P4HTMKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004963-A | TUMOR NECROSIS FACTOR RELEASE INHIBITORS; IMMUNOMODULATORS | GRUENENTHAL GMBH (DE) | 1999-12-21 | — | — | US | disclosed |