Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 13/20 | 0.69 |
| ▸ | JAK3 | P52333 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187462 | 0.85 | EGFR (0.75) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL4187517 | 0.84 | EGFR (0.85) | EGFRERBB2ERBB4JAK3ABL1 | |
| SCHEMBL4184896 | 0.83 | EGFR (0.78) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL7220061 | 0.78 | EGFR (0.79) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL4196716 | 0.78 | EGFR (0.74) | EGFRERBB2 | |
| SCHEMBL4350856 | 0.77 | EGFR (0.75) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL4194333 | 0.77 | EGFR (0.72) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL16994110 | 0.76 | EGFR (0.69) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL2993868 | 0.76 | EGFR (1.00) | EGFRERBB2ERBB4JAK3MEN1 | |
| SCHEMBL4180544 | 0.76 | EGFR (0.71) | EGFRERBB2ERBB4JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-01-27 | — | — | EP | claimed |
| WO-1997038983-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1997-10-23 | — | — | WO | claimed |