Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555949 | 0.85 | MAPT (0.63) | MAPTALDH1A1HCAR2LMNAMDM2 | |
| SCHEMBL23620720 | 0.85 | MAPT (0.63) | MAPTALDH1A1HCAR2LMNAMDM2 | |
| SCHEMBL9555945 | 0.85 | MAPT (0.63) | MAPTALDH1A1HCAR2LMNAMDM2 | |
| SCHEMBL6440534 | 0.79 | ALDH1A1 (0.62) | ALDH1A1TAAR1HCAR2LMNAPOLB | |
| SCHEMBL27735855 | 0.78 | HCAR2 (0.76) | MAPTALDH1A1HCAR2LMNAAKR1B10 | |
| SCHEMBL30661078 | 0.78 | HDAC3 (0.56) | MAPTALDH1A1TAAR1HDAC3HDAC4 | |
| SCHEMBL1268421 | 0.77 | MAPT (0.62) | MAPTHCAR2 | |
| SCHEMBL1268422 | 0.77 | MAPT (0.62) | MAPTHCAR2 | |
| SCHEMBL15610611 | 0.77 | MAPT (0.54) | MAPTALDH1A1TAAR1HDAC3HDAC4 | |
| SCHEMBL30866449 | 0.77 | MAPT (0.57) | MAPTALDH1A1HDAC8HDAC6HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5892040-A | Process for the manufacture of a tricyclic compound | PFIZER. INC (US) | 1999-04-06 | — | — | US | disclosed |
| EP-0680482-B1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND | PFIZER (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0680482-A1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND. | PFIZER (US) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994017074-A1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND | PFIZER INC. (US) | 1994-08-04 | — | — | WO | disclosed |