Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | PPID | Q08752 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.45 |
| ▸ | ADH1B | P00325 | 1/20 | 0.44 |
| ▸ | ADH1C | P00326 | 1/20 | 0.44 |
| ▸ | ADH1A | P07327 | 1/20 | 0.44 |
| ▸ | ADH7 | P40394 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555949 | 1.00 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1NPC1HPGD | |
| SCHEMBL9555945 | 1.00 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1NPC1HPGD | |
| SCHEMBL8470485 | 0.85 | MAPT (0.53) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL842765 | 0.79 | MAPT (0.60) | MAPTSMN1; SMN2ALDH1A1RAB9APPID | |
| SCHEMBL30866449 | 0.79 | MAPT (0.57) | MAPTSMN1; SMN2ALDH1A1NPC1HPGD | |
| SCHEMBL14577510 | 0.79 | MAPT (0.60) | MAPTSMN1; SMN2ALDH1A1RAB9APPID | |
| SCHEMBL842766 | 0.79 | MAPT (0.60) | MAPTSMN1; SMN2ALDH1A1RAB9APPID | |
| SCHEMBL15899383 | 0.78 | ALDH1A1 (0.62) | MAPTSMN1; SMN2ALDH1A1NPC1HPGD | |
| SCHEMBL15899385 | 0.78 | ALDH1A1 (0.62) | MAPTSMN1; SMN2ALDH1A1NPC1HPGD | |
| SCHEMBL20587799 | 0.78 | ALDH1A1 (0.61) | MAPTSMN1; SMN2ALDH1A1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059788-B2 | Streamlined syntheses of fluoroquinolones | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2021-07-13 | — | — | US | disclosed |
| CN-111032622-A | Streamlined synthetic fluoroquinolones | 弗吉尼亚联邦大学 | 2020-04-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059788-B2 | Streamlined syntheses of fluoroquinolones | NRAS, QARS1, BLM | MAPT 3184/4885SMN1; SMN2 3356/4885ALDH1A1 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.