Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26637678 | 0.92 | PDE5A (0.49) | PDE5ACA2CA9RAPGEF4POLB | |
| SCHEMBL15311992 | 0.87 | PDE5A (0.37) | PDE5ARAPGEF4POLBGAAL3MBTL1 | |
| SCHEMBL143706 | 0.87 | PDE5A (0.37) | PDE5ARAPGEF4POLBGAAL3MBTL1 | |
| SCHEMBL9541772 | 0.86 | CA12 (0.36) | PDE5ACA12CA2CA9RAPGEF4 | |
| SCHEMBL10771314 | 0.84 | CA12 (0.42) | PDE5ACA12CA2CA9RAPGEF4 | |
| SCHEMBL8971717 | 0.84 | CA12 (0.42) | PDE5ACA12CA2CA9RAPGEF4 | |
| SCHEMBL22328145 | 0.84 | PDE5A (0.35) | PDE5ARAPGEF4POLBGAAL3MBTL1 | |
| SCHEMBL9541748 | 0.83 | CA12 (0.35) | PDE5ACA12CA2CA9RAPGEF4 | |
| Ammonia Solution, Strong SCHEMBL4461425 | 0.82 | CA12 (0.34) | PDE5ACA12CA2CA9RAPGEF4 | |
| SCHEMBL15988135 | 0.81 | CA12 (0.36) | PDE5ACA12CA2CA9RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998417-A | PSYCHOLOGICAL DISORDERS; ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-07 | — | — | US | disclosed |