Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9541748 | 0.98 | CA12 (0.35) | CA12CA2CA9RAPGEF4POLB | |
| SCHEMBL9541772 | 0.92 | CA12 (0.36) | CA12CA2CA9RAPGEF4POLB | |
| SCHEMBL9544567 | 0.89 | RAPGEF4 (0.37) | RAPGEF4POLBGAAL3MBTL1MEP1B | |
| SCHEMBL419551 | 0.85 | NR3C1 (0.33) | CA12CA2CA9RAPGEF4POLB | |
| SCHEMBL419521 | 0.85 | NR3C1 (0.33) | CA12CA2CA9RAPGEF4POLB | |
| SCHEMBL8971717 | 0.82 | CA12 (0.42) | CA12CA2CA9RAPGEF4POLB | |
| SCHEMBL8470868 | 0.82 | PDE5A (0.44) | CA12CA2CA9RAPGEF4POLB | |
| SCHEMBL10771314 | 0.82 | CA12 (0.42) | CA12CA2CA9RAPGEF4POLB | |
| SCHEMBL30667042 | 0.81 | NR3C1 (0.36) | RAPGEF4POLBGAAL3MBTL1MEP1B | |
| SCHEMBL30666808 | 0.81 | NR3C1 (0.36) | RAPGEF4POLBGAAL3MBTL1MEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991526-B1 | Tetracyclic indole derivatives as in vivo imaging agents and having peripheralbenzodiazepine receptor affinity (PBR) | HAMMERSMITH IMANET LTD (GB) | 2014-02-12 | — | — | EP | disclosed |
| US-8506932-B2 | Tetracyclic indole derivatives as in vivo imaging agents and having peripheralbenzodiazepine receptor affinity (PBR) | HAMMERSMITH IMANET LIMITED (GB) | 2013-08-13 | — | — | US | disclosed |
| US-20090220420-A1 | TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR) | GE HEALTHCARE LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| EP-1991526-A1 | TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR) | Hammersmith Imanet, Ltd (GB) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007057705-A1 | TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR) | HAMMERSMITH IMANET LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090220420-A1 | TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR) | KIT, CNR1, CNR2 | CA12 3098/4885CA2 1962/4885CA9 2558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.