Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8473005 | 0.85 | PTGS1 (0.58) | PTGS1PTGS2PSEN1PSEN2APH1B | |
| SCHEMBL8473278 | 0.83 | PTGS2 (0.42) | PTGS1PTGS2PSEN1PSEN2APH1B | |
| SCHEMBL8470424 | 0.81 | PTGS2 (0.42) | PTGS1PTGS2PSEN1PSEN2APH1B | |
| SCHEMBL8473205 | 0.72 | PTGS2 (0.39) | PTGS1PTGS2 | |
| SCHEMBL8933887 | 0.64 | PTGS2 (0.71) | PTGS1PTGS2 | |
| SCHEMBL8472124 | 0.62 | PTGS2 (0.61) | PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL8635867 | 0.61 | PTGS2 (0.43) | PTGS1PTGS2 | |
| SCHEMBL8933829 | 0.60 | PTGS2 (1.00) | PTGS1PTGS2 | |
| SCHEMBL8643950 | 0.59 | PTGS2 (0.43) | PTGS1PTGS2 | |
| SCHEMBL8640824 | 0.59 | PTGS2 (0.42) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886016-A | ANTIINFLAMMATORY AGENT WITH MINIMAL SIDE EFFECTS FOR TREATING ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-03-23 | — | — | US | disclosed |