Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846035 | 0.91 | MEN1 (0.62) | TMPRSS4KDRNPC1RAB9AALDH1A1 | |
| SCHEMBL14516656 | 0.77 | NPC1 (0.68) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL330381 | 0.76 | TMPRSS4 (1.00) | TMPRSS4KDRNPC1RAB9AALDH1A1 | |
| SCHEMBL16627058 | 0.75 | NPC1 (0.78) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14339880 | 0.75 | IDO1 (0.65) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL995474 | 0.75 | KDR (1.00) | KDRNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL5578096 | 0.73 | NPC1 (0.81) | TMPRSS4KDRNPC1RAB9AALDH1A1 | |
| SCHEMBL14516654 | 0.73 | MEN1 (0.70) | MEN1KMT2ARXFP1PYGL | |
| SCHEMBL847002 | 0.73 | TMPRSS4 (0.53) | TMPRSS4KDRNPC1RAB9AALDH1A1 | |
| SCHEMBL935558 | 0.72 | NPC1 (0.70) | TMPRSS4KDRNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |