Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846035 | 0.81 | MEN1 (0.62) | TMPRSS4KDRMEN1KMT2AKDM4E | |
| SCHEMBL4108874 | 0.74 | KDR (0.63) | KDRPOLBCNR2KDM4ERAB9A | |
| SCHEMBL847146 | 0.73 | TMPRSS4 (0.61) | TMPRSS4KDRPOLBMEN1KMT2A | |
| SCHEMBL8568774 | 0.72 | KDM4E (0.67) | KDRPOLBMEN1KMT2AKDM4E | |
| SCHEMBL28908138 | 0.71 | KDR (0.62) | KDRPOLBKDM4ERAB9ANPC1 | |
| SCHEMBL15252595 | 0.70 | DGAT1 (0.55) | TMPRSS4KDRCNR2KDM4ERAB9A | |
| SCHEMBL7694592 | 0.69 | CNR1 (0.65) | TMPRSS4KDRPOLBMEN1KMT2A | |
| SCHEMBL3412727 | 0.69 | F7 (0.58) | MEN1KMT2AKDM4ERAB9ANPC1 | |
| SCHEMBL330381 | 0.69 | TMPRSS4 (1.00) | TMPRSS4KDRMEN1KMT2ARAB9A | |
| SCHEMBL28795062 | 0.69 | MEN1 (0.59) | MEN1KMT2AKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |