Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31574688 | 0.86 | MEP1B (0.39) | MEP1BMAPTPDCD1LG2CD274NPBWR1 | |
| SCHEMBL6353960 | 0.82 | AOC3 (0.41) | MEP1BMAPTALDH1A1 | |
| SCHEMBL14203437 | 0.82 | MEP1B (0.53) | MEP1BROCK2ROCK1CYP19A1ALDH1A1 | |
| SCHEMBL30937199 | 0.81 | ALOX5AP (0.42) | MEP1B | |
| SCHEMBL29255536 | 0.81 | MEP1B (0.35) | MEP1B | |
| SCHEMBL8470910 | 0.80 | MEP1B (0.51) | MEP1BROCK2ROCK1MAPTCYP19A1 | |
| SCHEMBL29673225 | 0.80 | MEP1B (0.48) | MEP1BROCK2ROCK1MAPTCYP19A1 | |
| SCHEMBL4592694 | 0.80 | MEP1B (0.51) | MEP1BROCK2ROCK1MAPTCYP19A1 | |
| SCHEMBL8274219 | 0.80 | MEP1B (0.48) | MEP1BROCK2ROCK1MAPTCYP19A1 | |
| SCHEMBL19251350 | 0.80 | MEP1B (0.48) | MEP1BROCK2ROCK1MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886016-A | ANTIINFLAMMATORY AGENT WITH MINIMAL SIDE EFFECTS FOR TREATING ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-03-23 | — | — | US | disclosed |
| WO-1996009304-A1 | BENZOPYRANOPYRAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |