Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659572 | 0.85 | MAPT (0.40) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL5262223 | 0.84 | CYP2D6 (0.40) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL5262226 | 0.84 | CYP2D6 (0.40) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL29281063 | 0.83 | CYP2D6 (0.43) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL9562413 | 0.82 | DHODH (0.57) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL30542821 | 0.82 | CYP2D6 (0.39) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL26363230 | 0.82 | CYP2D6 (0.39) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL10539251 | 0.82 | ALDH1A1 (0.39) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL9204037 | 0.82 | DHODH (0.57) | MAPTGAATDP1MEN1KMT2A | |
| SCHEMBL10539245 | 0.82 | ALDH1A1 (0.39) | MAPTGAATDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5892040-A | Process for the manufacture of a tricyclic compound | PFIZER. INC (US) | 1999-04-06 | — | — | US | disclosed |
| EP-0680482-B1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND | PFIZER (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0680482-A1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND. | PFIZER (US) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994017074-A1 | PROCESS FOR THE MANUFACTURE OF A TRICYCLIC COMPOUND | PFIZER INC. (US) | 1994-08-04 | — | — | WO | disclosed |