Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.31 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 4/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472907 | 0.96 | KCNH2 (0.37) | KCNH2MCHR1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL8470472 | 0.96 | KCNH2 (0.37) | KCNH2MCHR1CHRNB2CHRNA5CHRNA7 | |
| Hydrochloric Acid SCHEMBL8473022 | 0.95 | KCNH2 (0.37) | KCNH2MCHR1CHRNB2CHRNA5CHRNA7 | |
| Maleic Acid SCHEMBL8472381 | 0.90 | MAPT (0.39) | MEN1MAPTKMT2ATDP1PPARG | |
| Maleic Acid SCHEMBL6970543 | 0.86 | PPARG (0.40) | KCNH2MCHR1MEN1MAPTKMT2A | |
| SCHEMBL8470929 | 0.85 | MAPT (0.42) | MEN1MAPTKMT2ATDP1PPARG | |
| SCHEMBL8473756 | 0.85 | MAPT (0.42) | MEN1MAPTKMT2ATDP1PPARG | |
| Hydrochloric Acid SCHEMBL8472181 | 0.84 | MAPT (0.41) | MEN1MAPTKMT2ATDP1PPARG | |
| SCHEMBL6962690 | 0.82 | FFAR1 (0.42) | KCNH2MCHR1MEN1MAPTKMT2A | |
| SCHEMBL6962682 | 0.82 | FFAR1 (0.42) | KCNH2MCHR1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889032-A | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-03-30 | — | — | US | disclosed |