Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435014 | 0.86 | LIMK1 (0.48) | ALOX5PTPN1LIMK1ALDH1A1MAPT | |
| SCHEMBL25893684 | 0.85 | LIMK1 (0.36) | ALOX5PTPN1LIMK1CDK4CCND1 | |
| SCHEMBL8473965 | 0.84 | PTPN1 (0.52) | ALOX5PTPN1HSP90AA1LIMK1MEN1 | |
| SCHEMBL8471846 | 0.81 | HSP90AA1 (0.47) | ALOX5PTPN1HSP90AA1APPESR2 | |
| Iodide SCHEMBL29405457 | 0.80 | HSP90AA1 (0.46) | ALOX5PTPN1HSP90AA1APPESR2 | |
| SCHEMBL18820389 | 0.77 | APP (0.42) | ALOX5PTPN1APPESR2ESR1 | |
| SCHEMBL31006414 | 0.77 | APP (0.42) | ALOX5PTPN1APPESR2ESR1 | |
| SCHEMBL27741810 | 0.75 | ABL1 (0.45) | PTPN1ESR2ESR1CDK4CCND1 | |
| SCHEMBL5380464 | 0.74 | ALOX5 (0.69) | ALOX5PTPN1HSP90AA1APPESR2 | |
| Phenol SCHEMBL31695403 | 0.73 | F9 (0.44) | ALOX5PTPN1HSP90AA1APPLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001867-A | HYPOGLYCEMIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-14 | — | — | US | disclosed |