Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791945 | 0.81 | HRH3 (0.47) | KDM4EHSD17B10ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL5052466 | 0.76 | KDM4E (0.72) | KDM4EHSD17B10ALDH1A1HPGDCYP3A4 | |
| SCHEMBL3161270 | 0.75 | ALDH1A1 (0.56) | KDM4EHSD17B10ALDH1A1HPGDCYP3A4 | |
| SCHEMBL7803644 | 0.75 | KDM4E (0.58) | KDM4EHSD17B10ALDH1A1HPGDCYP3A4 | |
| SCHEMBL3847579 | 0.73 | MAPT (0.55) | HSD17B10ALDH1A1CYP3A4CYP2C9LMNA | |
| SCHEMBL596065 | 0.73 | KDM4E (0.72) | KDM4EHSD17B10ALDH1A1HPGDCYP3A4 | |
| SCHEMBL19134108 | 0.72 | FFAR4 (0.65) | KDM4EHSD17B10ALDH1A1HPGDCYP3A4 | |
| SCHEMBL15007834 | 0.72 | KDM4E (0.70) | KDM4EHSD17B10ALDH1A1HPGDCYP3A4 | |
| SCHEMBL12781875 | 0.72 | KDM4E (0.70) | KDM4EHSD17B10ALDH1A1HPGDCYP3A4 | |
| SCHEMBL15630682 | 0.72 | KDM4E (0.70) | KDM4EHSD17B10ALDH1A1HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977110-A | Substituted cyclohexylamines as central nervous systems agents | WARNER-LAMBERT COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1997011070-A1 | SUBSTITUTED CYCLOHEXYLAMINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-03-27 | — | — | WO | disclosed |
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |
| US-4988699-A | Treatment of psychological disorders such as schizophrenia, as antipsychotic agents and hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1991-01-29 | — | — | US | disclosed |