Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170101 | 0.87 | PTGS2 (0.50) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL8474169 | 0.84 | PTGS2 (0.50) | PTGS2PTGS1CA4CA2CA9 | |
| SCHEMBL8474198 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1CA1 | |
| SCHEMBL6169839 | 0.80 | PTGS2 (0.54) | PTGS2PTGS1CA4CA2CA9 | |
| SCHEMBL8475051 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1CA4CA2CA9 | |
| SCHEMBL8477502 | 0.79 | PTGS2 (0.51) | PTGS2PTGS1CA4CA2CA9 | |
| SCHEMBL8478643 | 0.79 | PTGS2 (0.53) | PTGS2PTGS1CA4CA2CA9 | |
| SCHEMBL8473865 | 0.78 | PTGS2 (0.50) | PTGS2PTGS1CA4CA2CA9 | |
| SCHEMBL8480053 | 0.78 | PTGS2 (0.47) | PTGS2PTGS1CA4CA2CA9 | |
| SCHEMBL8478784 | 0.78 | PTGS2 (0.49) | PTGS2PTGS1CA4CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |