Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.60 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2580228 | 0.76 | GPR119 (1.00) | GPR119F10 | |
| SCHEMBL1754736 | 0.74 | GPR119 (0.61) | GPR119SMN1; SMN2RAB9AALDH1A1PDE3B | |
| SCHEMBL11090412 | 0.73 | PDE3B (0.63) | GPR119SMN1; SMN2RAB9AALDH1A1PDE3B | |
| SCHEMBL16157206 | 0.73 | PBRM1 (1.00) | GPR119PBRM1PDE3BPDE3A | |
| SCHEMBL20522794 | 0.72 | AXL (0.53) | GPR119PBRM1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11402071 | 0.72 | GPR119 (0.62) | GPR119SMN1; SMN2RAB9AALDH1A1PDE3B | |
| SCHEMBL8478610 | 0.71 | GPR119 (0.56) | GPR119PBRM1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7272078 | 0.71 | PDE3B (0.64) | GPR119SMN1; SMN2RAB9AALDH1A1PDE3B | |
| SCHEMBL8483017 | 0.70 | GPR119 (0.44) | GPR119ALDH1A1PDE3BPDE3AMAPT | |
| SCHEMBL11402076 | 0.70 | GPR119 (0.53) | GPR119SMN1; SMN2RAB9AALDH1A1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883090-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-03-16 | — | — | US | disclosed |
| EP-0796250-A1 | PYRIDAZINONES AS ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1997-09-24 | — | — | EP | disclosed |
| WO-1997013758-A1 | PYRIDAZINONES AS ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-04-17 | — | — | WO | disclosed |