Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8478610 | 0.84 | GPR119 (0.56) | AXLPBRM1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31553378 | 0.75 | PDE3B (0.44) | PBRM1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL19205895 | 0.72 | ALDH1A1 (0.44) | PBRM1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL8475012 | 0.72 | GPR119 (0.60) | PBRM1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL2375581 | 0.69 | AXL (1.00) | AXLSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL16157206 | 0.69 | PBRM1 (1.00) | PBRM1GPR119PDE3BPDE3A | |
| SCHEMBL5566954 | 0.68 | AXL (0.69) | AXLSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL6857445 | 0.68 | AXL (0.44) | AXLSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL11710676 | 0.68 | NOTUM (0.46) | PBRM1SMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6849455 | 0.68 | AXL (0.58) | AXLSMN1; SMN2ALDH1A1GPR119CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11617738-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | PURDUE RESEARCH FOUNDATION (US) | 2023-04-04 | — | — | US | disclosed |
| US-20210196684-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2021-07-01 | — | — | US | disclosed |
| US-20210196684-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2021-07-01 | — | — | US | disclosed |
| US-10980781-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | PURDUE RESEARCH FOUNDATION (US) | 2021-04-20 | — | — | US | disclosed |
| US-10980781-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | PURDUE RESEARCH FOUNDATION (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200078336-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2020-03-12 | — | — | US | disclosed |
| WO-2018183587-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2018-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200078336-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | USP7, USP3, USP2 | AXL 2748/4885PBRM1 2382/4885SMN1; SMN2 3552/4885 |
| US-20210196684-A1 | 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE | USP7, USP3, USP2 | AXL 2748/4885PBRM1 2382/4885SMN1; SMN2 3552/4885 |
| US-10980781-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | USP7, USP3, USP2 | AXL 2748/4885PBRM1 2382/4885SMN1; SMN2 3552/4885 |
| US-11617738-B2 | 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use | USP7, USP3, USP2 | AXL 2748/4885PBRM1 2382/4885SMN1; SMN2 3552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.