Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593235 | 0.72 | GLS (0.49) | TACR1KMT2AMEN1GLSOPRD1 | |
| SCHEMBL7985622 | 0.70 | GAA (0.50) | TACR1KMT2AMEN1GLSOPRM1 | |
| SCHEMBL5410711 | 0.70 | ATM (0.50) | TACR1KMT2AMEN1GLSOPRL1 | |
| SCHEMBL8473434 | 0.70 | GLS (0.46) | TACR1KMT2AMEN1GLSALDH1A1 | |
| SCHEMBL14593385 | 0.68 | MEN1 (0.46) | TACR1KMT2AMEN1GLS | |
| SCHEMBL4702559 | 0.68 | GPR119 (0.50) | KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL14593289 | 0.67 | ABCB1 (0.51) | TACR1KMT2AMEN1GLSALDH1A1 | |
| SCHEMBL14593418 | 0.66 | MC4R (0.60) | TACR1GLS | |
| SCHEMBL4483290 | 0.66 | SLC6A2 (0.45) | KMT2AMEN1ALDH1A1CNR1CNR2 | |
| SCHEMBL28714150 | 0.65 | GPR119 (0.50) | KMT2AMEN1GLSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925638-A | Substituted 1-indolylpropyl-4-benzylpiperazine derivatives | MERCK SHARP & DOHME LTD. (GB) | 1999-07-20 | — | — | US | disclosed |
| WO-1997017338-A1 | SUBSTITUTED 1-INDOLYLPROPYL-4-BENZYLPIPERAZINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-15 | — | — | WO | disclosed |