Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | METAP2 | P50579 | 9/20 | 0.52 |
| ▸ | METAP1 | P53582 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | CBFB | Q13951 | 9/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8477890 | 0.93 | NPC1 (0.58) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL548420 | 0.89 | NISCH (0.46) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL13866553 | 0.82 | NPC1 (0.74) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL7191697 | 0.82 | NISCH (0.41) | NPC1RAB9AKDM4EKMT2AGAA | |
| SCHEMBL548343 | 0.82 | NISCH (0.50) | NISCH | |
| SCHEMBL8677423 | 0.82 | NISCH (0.50) | NISCH | |
| SCHEMBL8475093 | 0.80 | NPC1 (0.50) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL8164925 | 0.80 | GAA (0.50) | KMT2AMETAP2METAP1CBFBGAA | |
| SCHEMBL548421 | 0.80 | GAA (0.50) | KMT2AMETAP2METAP1CBFBGAA | |
| SCHEMBL10351277 | 0.79 | NPC1 (0.68) | NPC1RAB9APKMLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939440-A | FUNGICIDES AND BACTERICIDES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-08-17 | — | — | US | claimed |
| US-5792782-A | TREATING CRYPTOCOCCUS NEOFORMANS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-08-11 | — | — | US | claimed |
| US-5939440-A | FUNGICIDES AND BACTERICIDES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-08-17 | — | — | US | disclosed |
| US-5935982-A | ADMINISTERING ARYLENEBIS((AMIDINO)-2-BENZIMIDAZOLE) DERIVATIVES TO TREAT HUMAN T-CELL LEUKEMIA/LYMPHOMA VIRUS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-08-10 | — | — | US | disclosed |
| US-5817687-A | LEUKEMIA | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-10-06 | — | — | US | disclosed |
| US-5817686-A | CANDIDA ALBICANS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-10-06 | — | — | US | disclosed |
| US-5792782-A | TREATING CRYPTOCOCCUS NEOFORMANS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-08-11 | — | — | US | disclosed |