Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 1/20 | 0.39 |
| ▸ | HEXB | P07686 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8473764 | 0.86 | ALOX5AP (0.37) | CA2CA1CA12CA9MEN1 | |
| SCHEMBL8479645 | 0.86 | PTGS2 (0.41) | CA2CA1CA12CA9BRD4 | |
| SCHEMBL8481485 | 0.85 | F10 (0.39) | CA2CA1CA12CA9BRD4 | |
| SCHEMBL8479990 | 0.84 | PTGS2 (0.40) | HEXAHEXBCA2CA1CA12 | |
| SCHEMBL6170459 | 0.83 | CA2 (0.55) | CA2CA1CA12CA9LMNA | |
| SCHEMBL8476610 | 0.83 | F10 (0.39) | HEXAHEXBCA2CA1CA12 | |
| SCHEMBL8478775 | 0.82 | CHEK1 (0.39) | HEXAHEXBCA2CA1BRD4 | |
| SCHEMBL8475639 | 0.82 | BRD4 (0.41) | CA2CA1BRD4BRD2BRD3 | |
| SCHEMBL8473985 | 0.82 | PTGS2 (0.43) | CA2CA9PTGS1PTGS2 | |
| SCHEMBL8481523 | 0.80 | PTGS2 (0.41) | CA2CA9PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |