Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.42 |
| ▸ | RARB | P10826 | 6/20 | 0.42 |
| ▸ | RARG | P13631 | 5/20 | 0.42 |
| ▸ | RXRA | P19793 | 7/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 4/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6757746 | 0.86 | PTGS1 (0.45) | RARARARBRARGRXRARXRB | |
| SCHEMBL6756499 | 0.86 | PTGS1 (0.45) | RARARARBRARGRXRARXRB | |
| SCHEMBL29653694 | 0.82 | RXRA (0.48) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL21017967 | 0.82 | RXRA (0.48) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL8332791 | 0.82 | RXRA (0.48) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL8606352 | 0.82 | RXRA (0.48) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL8332983 | 0.82 | RXRA (0.48) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL6186833 | 0.74 | PTGS1 (0.31) | PTGS1PTGS2SLC6A2SLC6A4 | |
| SCHEMBL8672117 | 0.74 | RARB (0.43) | RARARARBRARGRXRARXRB | |
| SCHEMBL8667594 | 0.74 | RARA (0.40) | RARARARBRARGRXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999008992-A1 | 2,4-PENTADIENOIC ACID DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1999-02-25 | — | — | WO | disclosed |
| EP-0848696-A1 | 2,4-PENTADIENOIC ACID DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan (US) | 1998-06-24 | — | — | EP | disclosed |