Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170950 | 0.88 | BRD4 (0.50) | BRD4BRD2TDO2ALDH1A1MAPT | |
| SCHEMBL6167859 | 0.83 | NPC1 (0.38) | BRD4BRD2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21105338 | 0.77 | BRD4 (0.68) | BRD4BRD2TDO2ALDH1A1MAPT | |
| SCHEMBL6514118 | 0.74 | LMNA (0.37) | BRD4BRD2TDO2ALDH1A1MAPT | |
| SCHEMBL72613 | 0.73 | AR (0.43) | SMN1; SMN2NPC1RAB9AHPGDLMNA | |
| SCHEMBL6169678 | 0.71 | PTGS2 (0.43) | BRD4TDO2ALDH1A1MAPTNPC1 | |
| SCHEMBL6511644 | 0.69 | BRD4 (0.56) | BRD4BRD2TDO2ALDH1A1MAPT | |
| SCHEMBL3751072 | 0.68 | BRD4 (0.53) | BRD4BRD2TDO2ALDH1A1MAPT | |
| SCHEMBL6170416 | 0.67 | PTGS1 (0.60) | BRD4BRD2TDO2ALDH1A1MAPT | |
| SCHEMBL8475581 | 0.67 | BRD4 (0.53) | BRD4BRD2TDO2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |