Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 8/20 | 0.46 |
| ▸ | EDNRA | P25101 | 8/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480037 | 0.82 | TSHR (0.43) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8479006 | 0.81 | EDNRB (0.60) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8473816 | 0.80 | NMT1 (0.43) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8525137 | 0.80 | EDNRA (0.55) | TSHRMAPK1EDNRBEDNRASLC40A1 | |
| SCHEMBL8479643 | 0.78 | TSHR (0.46) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8477509 | 0.77 | TSHR (0.45) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8476543 | 0.76 | TSHR (0.44) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8473314 | 0.76 | LIMK2 (0.52) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8475016 | 0.75 | ALDH1A1 (0.49) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8474213 | 0.75 | EDNRB (0.56) | TSHRMAPK1EDNRBEDNRAFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |