Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 6/20 | 0.46 |
| ▸ | EDNRA | P25101 | 6/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481482 | 0.92 | TSHR (0.45) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8473983 | 0.91 | HSD11B1 (0.43) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8476543 | 0.89 | TSHR (0.44) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8478773 | 0.89 | MCL1 (0.46) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8475707 | 0.88 | TSHR (0.42) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8477509 | 0.88 | TSHR (0.45) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8473571 | 0.87 | TRPV1 (0.46) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8473314 | 0.86 | LIMK2 (0.52) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8473816 | 0.85 | NMT1 (0.43) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8475213 | 0.84 | EDNRB (0.45) | TSHRMAPK1EDNRBEDNRAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |