Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 6/20 | 0.55 |
| ▸ | DNMT3A | Q9Y6K1 | 4/20 | 0.55 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847682 | 0.80 | S1PR1 (0.55) | DNMT1DNMT3ADNMT3LS1PR1S1PR3 | |
| SCHEMBL846053 | 0.78 | TRPV1 (0.70) | SMN1; SMN2TRPV1 | |
| SCHEMBL12240483 | 0.72 | DNMT1 (0.71) | DNMT1DNMT3ADNMT3LS1PR1S1PR3 | |
| SCHEMBL846205 | 0.71 | TRPV1 (0.45) | DNMT1DNMT3ADNMT3LS1PR1MEN1 | |
| SCHEMBL13140149 | 0.69 | DNMT1 (0.95) | DNMT1DNMT3ADNMT3LHDAC6HDAC3 | |
| SCHEMBL12217951 | 0.69 | DNMT1 (0.95) | DNMT1DNMT3ADNMT3LHDAC6HDAC3 | |
| SCHEMBL4935713 | 0.69 | TRPV1 (0.48) | HDAC6MEN1KMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL1749861 | 0.69 | SRD5A2 (0.49) | KMT2ASMN1; SMN2PTPN1 | |
| SCHEMBL6911011 | 0.68 | MEN1 (0.59) | HDAC6HDAC3HDAC1HDAC2MEN1 | |
| SCHEMBL28238219 | 0.68 | DNMT1 (0.78) | DNMT1DNMT3ADNMT3LHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |