SCHEMBL8477435

SCHEMBL8477435

OCCC(O)CCc1cccnc1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.50
KDM4E B2RXH2 1/20 0.49
CYP2A6 P11509 1/20 0.47
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TBXAS1 P24557 7/20 0.45
HRH1 P35367 2/20 0.45
CYP1A2 P05177 2/20 0.44
CYP2D6 P10635 2/20 0.44
NAPRT Q6XQN6 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5016747 0.93 CHRNA7 (0.57) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL6950222 0.88 CHRNA7 (0.52) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL6950227 0.88 CHRNA7 (0.52) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL7831473 0.88 CHRNA7 (0.52) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL6014381 0.85 CHRNA7 (0.62) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL6950753 0.83 TDP1 (0.54) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL10034621 0.83 TDP1 (0.54) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL6946868 0.83 CHRNA7 (0.50) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL3923399 0.82 CYP2A6 (0.59) CHRNA7KDM4ECYP2A6TDP1L3MBTL1
SCHEMBL8464889 0.82 TBXAS1 (0.53) CHRNA7CYP2A6TDP1L3MBTL1TBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5977105-A Compounds ASTRA PHARMAEUTICALS LTD. (GB) 1999-11-02 US claimed
EP-0865431-A2 COMPOUNDS Astra Pharmaceuticals Limited (GB) 1998-09-23 EP claimed
WO-1997020815-A1 COMPOUNDS ASTRA PHARMACEUTICALS LTD. (GB) 1997-06-12 WO claimed
US-5977105-A Compounds ASTRA PHARMAEUTICALS LTD. (GB) 1999-11-02 US disclosed
CN-1208403-A Compounds BRITISH ASTRA PHARMACEUTICALS (GB) 1999-02-17 CN disclosed
EP-0865431-A2 COMPOUNDS Astra Pharmaceuticals Limited (GB) 1998-09-23 EP disclosed
WO-1997020815-A1 COMPOUNDS ASTRA PHARMACEUTICALS LTD. (GB) 1997-06-12 WO disclosed