SCHEMBL8478571

SCHEMBL8478571

Cc1cc(Oc2ccnc(OC(F)F)c2)nc(Oc2ccnc(OC(F)F)c2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 7/20 0.39
RXRA P19793 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2B Q13224 1/20 0.34
CRHR1 P34998 2/20 0.33
UTRN P46939 1/20 0.33
BACE1 P56817 1/20 0.33
GPR39 O43194 1/20 0.33
DRD1 P21728 1/20 0.32
BLM P54132 1/20 0.32
LOXL2 Q9Y4K0 1/20 0.32
MEN1 O00255 1/20 0.32
CYP1A2 P05177 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32
CYP2C19 P33261 1/20 0.32
KMT2A Q03164 1/20 0.32
ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8475249 0.86 LMNA (0.39) RXRAGRIN1GRIN2BLOXL2MEN1
SCHEMBL6610955 0.84 F2RL3 (0.33) F2RL3
SCHEMBL8126005 0.84 BLM (0.31) F2RL3BLM
SCHEMBL8475743 0.83 MAPK14 (0.38) F2RL3RXRAGRIN1GRIN2BMEN1
SCHEMBL8475344 0.83 PIM1 (0.34) RXRAGRIN1GRIN2B
SCHEMBL6610768 0.83 F2RL3 (0.30) F2RL3
SCHEMBL6608706 0.82 F2RL3 (0.30) F2RL3
SCHEMBL6610025 0.81
SCHEMBL6610026 0.80 F2RL3 (0.31) F2RL3
SCHEMBL16642357 0.80 UHRF1 (0.45) F2RL3RXRAGRIN1GRIN2BCRHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5922738-A Heteroarylpyridine herbicides AMERICAN CYANAMID COMPANY (US) 1999-07-13 US claimed
US-5922738-A Heteroarylpyridine herbicides AMERICAN CYANAMID COMPANY (US) 1999-07-13 US disclosed