SCHEMBL8475249

SCHEMBL8475249

Cc1cc(OCc2ccc(F)cc2)nc(Oc2ccnc(OC(F)F)c2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.39
KDM4E B2RXH2 1/20 0.39
TSHR P16473 1/20 0.39
MAPK1 P28482 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
MAPK14 Q16539 2/20 0.36
RXRA P19793 1/20 0.36
GRIN1 Q05586 1/20 0.36
GRIN2B Q13224 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
STAT3 P40763 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
GRM5 P41594 1/20 0.35
GABRA5 P31644 1/20 0.35
MAOB P27338 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8478571 0.86 F2RL3 (0.39) MAPK1L3MBTL1MEN1KMT2ARXRA
SCHEMBL8475344 0.84 PIM1 (0.34) RXRAGRIN1GRIN2BGABRA5MCHR1
SCHEMBL8475743 0.80 MAPK14 (0.38) LMNAKDM4ETSHRMAPK1MEN1
SCHEMBL6610955 0.76 F2RL3 (0.33)
SCHEMBL6610768 0.75 F2RL3 (0.30)
SCHEMBL6608706 0.74 F2RL3 (0.30)
SCHEMBL8278886 0.73 LMNA (0.45) LMNAKDM4ETSHRMAPK1TDP1
SCHEMBL6610026 0.73 F2RL3 (0.31)
SCHEMBL9005108 0.73 GABRA5 (0.48) LMNAL3MBTL1GABRA5MAOBNR4A2
SCHEMBL6611091 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5922738-A Heteroarylpyridine herbicides AMERICAN CYANAMID COMPANY (US) 1999-07-13 US claimed
US-5922738-A Heteroarylpyridine herbicides AMERICAN CYANAMID COMPANY (US) 1999-07-13 US disclosed