Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 13/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481533 | 0.86 | LSS (0.64) | LSSKDM4EMEN1MAPTKMT2A | |
| SCHEMBL8760852 | 0.83 | LSS (0.55) | LSSKDM4EMEN1MAPTKMT2A | |
| SCHEMBL8760860 | 0.81 | LSS (0.68) | LSS | |
| SCHEMBL8484710 | 0.81 | LSS (0.55) | LSSKDM4EMEN1MAPTKMT2A | |
| SCHEMBL8760752 | 0.80 | LSS (1.00) | LSS | |
| SCHEMBL8484409 | 0.79 | LSS (0.55) | LSSKDM4EMEN1MAPTKMT2A | |
| SCHEMBL8478774 | 0.77 | LSS (0.69) | LSS | |
| SCHEMBL8483271 | 0.77 | LSS (0.66) | LSSALDH2MAOAMAOB | |
| SCHEMBL8478712 | 0.75 | LSS (0.50) | LSS | |
| SCHEMBL5038612 | 0.75 | LSS (0.70) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067991-C | Aminoalkyl subsetd. benzo-heterocyclic compounds | HOFFMANN LA ROCHE (CH) | 2001-07-04 | — | — | CN | disclosed |
| US-5856503-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| CN-1161328-A | Aminoalkyl subsetd. benzo-heterocyclic compounds | HOFFMANN LA ROCHE (CH) | 1997-10-08 | — | — | CN | disclosed |
| EP-0778271-A2 | Aminoalkyl-substituted benzo-heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |