Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pinacidil Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 known ✓ | O60706 | 9/20 | 0.53 |
| ▸ | KCNJ11 known ✓ | Q14654 | 9/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pinacidil Anhydrous SCHEMBL65786 | 1.00 | ABCC9 (0.53) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| Pinacidil Anhydrous SCHEMBL504208 | 1.00 | ABCC9 (0.53) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| Pinacidil Anhydrous SCHEMBL9275522 | 1.00 | ABCC9 (0.53) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| Pinacidil Anhydrous SCHEMBL5051662 | 1.00 | ABCC9 (0.53) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| Pinacidil Anhydrous SCHEMBL7061536 | 0.92 | ABCC9 (0.46) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL9298624 | 0.84 | KIF11 (0.54) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL11158589 | 0.80 | ABCC9 (0.48) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL8141227 | 0.78 | KCNJ11 (0.39) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL24872316 | 0.77 | CYP3A4 (0.44) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL11164606 | 0.76 | CYP3A4 (0.41) | ABCC9KCNJ11CYP3A4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877184-A | Macrolides having immunosuppressive activity | MERCK & CO., INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0722448-A4 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO INC (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5693648-A | TREATMENT OF AUTOIMMUNE DISEASES, INFECTIOUS DISEASES, PREVENTING REJECTION OF ORGAN TRANSPLANTS | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5578599-A | SYNERGISTIC | THE UPJOHN COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| US-5565560-A | TREATING AUTOIMMUNE DISEASES, PREVENTING TRANSPLANT REJECTION | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0722448-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO. INC. (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5532248-A | O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity | MERCK CO., INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0542802-B1 | STIMULATION OF HAIR GROWTH WITH POTASSIUM CHANNEL OPENERS AND 5-ALPHA-REDUCTASE INHIBITORS | UPJOHN CO (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1995017387-A1 | A NOVEL PROCESS FOR PREPARING N''-CYANO-N'-(4-PYRIDYL)-N-(1,2,2-TRIMETHYLPROPYL)-GUANIDINE | EGIS Gyógyszergyár Rt. (HU) | 1995-06-29 | — | — | WO | disclosed |
| WO-1995009857-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| US-5349061-A | O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity | MERCK & CO., INC. (US) | 1994-09-20 | — | — | US | disclosed |
| US-5344925-A | Autoimmune diseases; infections; organ transplants | MERCK & CO., INC. (US) | 1994-09-06 | — | — | US | disclosed |
| WO-1992009259-A1 | STIMULATION OF HAIR GROWTH WITH POTASSIUM CHANNEL OPENERS AND AN ANDROGEN RECEPTOR BLOCKER | THE UPJOHN COMPANY (US) | 1992-06-11 | — | — | WO | disclosed |
| US-5087640-A | Potassium channel openers; hypotensive agents, coronary vasodilators | KANEBO, LTD. (JP) | 1992-02-11 | — | — | US | disclosed |