Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | PARP1 | P09874 | 2/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480165 | 0.89 | ALDH1A1 (0.66) | ALDH1A1KDM4EHSD17B10MAPTCYP2C19 | |
| SCHEMBL3536679 | 0.79 | CYP2C19 (0.69) | ALDH1A1KDM4EHSD17B10MAPTCYP2C19 | |
| SCHEMBL16792539 | 0.78 | BTK (0.51) | ALDH1A1KDM4EHSD17B10MAPTPARP1 | |
| SCHEMBL28624628 | 0.77 | KDM4E (1.00) | ALDH1A1KDM4EHSD17B10MAPTCYP2C19 | |
| SCHEMBL4811540 | 0.74 | POLB (0.60) | ALDH1A1KDM4ECYP2C19CYP2D6CYP1A2 | |
| SCHEMBL20982709 | 0.74 | HDAC6 (0.68) | ALDH1A1KDM4ECYP2C19CYP2D6CYP1A2 | |
| SCHEMBL14435528 | 0.74 | POLB (1.00) | ALDH1A1KDM4ECYP2C19CYP2D6CYP1A2 | |
| SCHEMBL25811210 | 0.74 | KMT2A (0.70) | ALDH1A1KDM4EHSD17B10MAPTCYP2C19 | |
| SCHEMBL18845433 | 0.74 | CYP2C19 (0.78) | ALDH1A1KDM4ECYP2C19CYP2D6CYP1A2 | |
| SCHEMBL3543383 | 0.73 | CYP2C9 (0.71) | ALDH1A1KDM4ECYP2C19CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985909-A | Cyclopropylindoles and their seco precursors, and their use as prodrugs | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-11-16 | — | — | US | disclosed |
| EP-0850220-A1 | CYCLOPROPYLINDOLES AND THEIR SECO PRECURSORS, AND THEIR USE AS PRODRUGS | AUCKLAND DIVISION CANCER SOCIETY OF NEW ZEALAND INC. (NZ) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997007097-A1 | CYCLOPROPYLINDOLES AND THEIR SECO PRECURSORS, AND THEIR USE AS PRODRUGS | AUCKLAND DIVISION CANCER SOCIETY OF NEW ZEALAND INC. (NZ) | 1997-02-27 | — | — | WO | disclosed |