Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 7/20 | 0.46 |
| ▸ | EDNRA | P25101 | 7/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8478508 | 0.88 | ALDH1A1 (0.46) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL8476395 | 0.85 | ALDH1A1 (0.49) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL8479431 | 0.84 | ALDH1A1 (0.46) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL8473298 | 0.83 | ALDH1A1 (0.47) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL8473119 | 0.82 | ALDH1A1 (0.49) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL8475016 | 0.80 | ALDH1A1 (0.49) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL8478953 | 0.80 | ALDH1A1 (0.47) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL8477539 | 0.78 | FAAH (0.50) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL8475169 | 0.78 | ALDH1A1 (0.46) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 | |
| SCHEMBL6435523 | 0.78 | ALDH1A1 (0.63) | ALDH1A1NPSR1EDNRBEDNRAMT-CO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |