Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 5/20 | 0.41 |
| ▸ | EDNRA | P25101 | 5/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479643 | 0.88 | TSHR (0.46) | TSHRMAPK1EDNRBEDNRARORC | |
| SCHEMBL8478773 | 0.87 | MCL1 (0.46) | TSHRMAPK1EDNRBEDNRAPTPN1 | |
| SCHEMBL8473983 | 0.87 | HSD11B1 (0.43) | TSHRMAPK1EDNRBEDNRAHSD11B1 | |
| SCHEMBL8475638 | 0.87 | TSHR (0.43) | TSHRMAPK1EDNRBEDNRA | |
| SCHEMBL8474159 | 0.82 | TP53 (0.43) | KAT6AALDH1A1 | |
| SCHEMBL8481482 | 0.81 | TSHR (0.45) | TSHRMAPK1EDNRBEDNRAALDH1A1 | |
| SCHEMBL8473763 | 0.80 | EDNRB (0.41) | TSHRMAPK1EDNRBEDNRAALDH1A1 | |
| SCHEMBL8476543 | 0.78 | TSHR (0.44) | TSHRMAPK1EDNRBEDNRARORC | |
| SCHEMBL8477556 | 0.78 | PTGS2 (0.45) | TSHRALDH1A1 | |
| SCHEMBL8477509 | 0.77 | TSHR (0.45) | TSHRMAPK1EDNRBEDNRARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |