Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 7/20 | 0.38 |
| ▸ | GAA | P10253 | 7/20 | 0.38 |
| ▸ | SI | P14410 | 7/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HEXA | P06865 | 1/20 | 0.37 |
| ▸ | HEXB | P07686 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8474318 | 0.89 | ESR2 (0.41) | PDE4APDE4BPDE4CPDE4DESR2 | |
| SCHEMBL8482098 | 0.88 | PDE4B (0.56) | PDE4APDE4BPDE4CPDE4DESR2 | |
| SCHEMBL8480669 | 0.81 | HEXA (0.38) | ESR2ESR1GAAHEXAHEXB | |
| SCHEMBL8474890 | 0.78 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4DESR2 | |
| SCHEMBL8479017 | 0.78 | MGAM (0.42) | MGAMGAASIMGAM2MAOB | |
| SCHEMBL8477575 | 0.78 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4DMGAM | |
| SCHEMBL8474433 | 0.78 | MGAM (0.39) | PDE4APDE4BPDE4CPDE4DMGAM | |
| SCHEMBL8478650 | 0.77 | PDE4B (0.53) | PDE4APDE4BPDE4CPDE4DMGAM | |
| SCHEMBL8480085 | 0.77 | PDE4B (0.38) | PDE4APDE4BPDE4CPDE4DESR2 | |
| SCHEMBL8477631 | 0.76 | PDE4B (0.42) | PDE4APDE4BPDE4CPDE4DHEXA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004988-A | Carboxylic acid derivatives, their preparation and their use | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-21 | — | — | US | disclosed |