SCHEMBL8474433

SCHEMBL8474433

CCc1[c]c(-c2ccc(OC)c(C)c2)c(-c2ccc(OC)c(C)c2)c(O)c1OC

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MGAM O43451 10/20 0.39
GAA P10253 10/20 0.39
SI P14410 10/20 0.39
MGAM2 Q2M2H8 10/20 0.39
PDE4A P27815 5/20 0.36
PDE4B Q07343 5/20 0.36
PDE4C Q08493 5/20 0.36
PDE4D Q08499 5/20 0.36
SLC10A2 Q12908 1/20 0.35
ALOX5 P09917 1/20 0.33
EPHX2 P34913 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8478485 0.90 MGAM (0.36) MGAMGAASIMGAM2PDE4A
SCHEMBL8480653 0.85 SLC10A2 (0.39) SLC10A2
SCHEMBL8474699 0.81 MAPT (0.37) MGAMGAASIMGAM2PDE4A
SCHEMBL8581223 0.79 MAPK1 (0.36) MGAMGAASIMGAM2SLC10A2
SCHEMBL8478465 0.78 KDM4E (0.35) PDE4APDE4BPDE4CPDE4DSLC10A2
SCHEMBL8479986 0.78 PDE4A (0.41) MGAMGAASIMGAM2PDE4A
SCHEMBL8583197 0.78 PTGS2 (0.35) MGAMGAASIMGAM2PDE4A
SCHEMBL8482098 0.77 PDE4B (0.56) MGAMGAASIMGAM2PDE4A
SCHEMBL8475146 0.77 MGAM (0.42) MGAMGAASIMGAM2
SCHEMBL8581095 0.76 MAPK1 (0.36) MGAMGAASIMGAM2SLC10A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6004988-A Carboxylic acid derivatives, their preparation and their use BASF AKTIENGESELLSCHAFT (DE) 1999-12-21 US disclosed