Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.47 |
| ▸ | GCGR | P47871 | 6/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | CBFB | Q13951 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8475950 | 0.88 | MAPK14 (0.45) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL8480160 | 0.85 | MAPK14 (0.49) | TGFBR1MAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL8479495 | 0.85 | MAPK14 (0.49) | TGFBR1MAPK14CSNK1DCSNK1EMETAP2 | |
| SCHEMBL6960991 | 0.81 | MAPK14 (0.72) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL5921871 | 0.81 | MAPK14 (0.72) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL8476402 | 0.79 | MAPK13 (0.47) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL4526549 | 0.76 | TGFBR1 (0.53) | TGFBR1MAPK14MAPK13GCGRMAPK12 | |
| SCHEMBL5623031 | 0.76 | KDM4E (0.57) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL8481652 | 0.74 | MAPK13 (0.43) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL8480021 | 0.74 | MAPK13 (0.44) | MAPK14MAPK13GCGRMAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5959113-A | REACTING A DIKETONE DERIVATIVE WITH AN ALDEHYDE DERIVATIVE; ADMINISTERING TO TREAT ATHEROSCLEROSIS, PSORIASIS, ALOPECIA AND TUMORS | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | claimed |
| US-5959113-A | REACTING A DIKETONE DERIVATIVE WITH AN ALDEHYDE DERIVATIVE; ADMINISTERING TO TREAT ATHEROSCLEROSIS, PSORIASIS, ALOPECIA AND TUMORS | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |