Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479739 | 0.99 | MRGPRX4 (0.39) | MRGPRX4ERAP1MAPTRARARARB | |
| SCHEMBL8481719 | 0.83 | MAPT (0.41) | MAPT | |
| SCHEMBL8478791 | 0.83 | EGFR (0.36) | — | |
| SCHEMBL8480273 | 0.79 | MRGPRX4 (0.41) | MRGPRX4ERAP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8479735 | 0.78 | MRGPRX4 (0.41) | MRGPRX4ERAP1MAPTRARARARB | |
| SCHEMBL8477001 | 0.74 | EGFR (0.37) | ALDH1A1HPGDKDM4E | |
| SCHEMBL8480189 | 0.73 | ERAP1 (0.46) | ERAP1ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL8476017 | 0.72 | ERAP1 (0.44) | ERAP1ALDH1A1MAPTHPGDTSHR | |
| SCHEMBL8480277 | 0.69 | ERAP1 (0.40) | ERAP1ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL6215857 | 0.69 | ALDH1A1 (0.44) | ERAP1ALDH1A1SMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914406-A | ENZYME INHIBITOR; USEFUL FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMAN-LA ROCHE INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5750706-A | TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |