Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | RARG | P13631 | 5/20 | 0.38 |
| ▸ | RARA | P10276 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480273 | 0.99 | MRGPRX4 (0.41) | MRGPRX4PDE4DRARGRARARARB | |
| SCHEMBL8478786 | 0.84 | PDE4D (0.41) | MRGPRX4PDE4DRARGEGFRPPARD | |
| SCHEMBL8481711 | 0.84 | PDE4D (0.46) | MRGPRX4PDE4DRARGEGFRPPARD | |
| SCHEMBL8479739 | 0.78 | MRGPRX4 (0.39) | MRGPRX4RARGRARARARBEGFR | |
| SCHEMBL8480279 | 0.78 | MRGPRX4 (0.38) | MRGPRX4RARGRARARARBERAP1 | |
| SCHEMBL8476993 | 0.76 | EGFR (0.40) | PDE4DRARARARBEGFRPPARD | |
| SCHEMBL8476017 | 0.71 | ERAP1 (0.44) | RARGRARARARBEGFRERAP1 | |
| SCHEMBL8480189 | 0.70 | ERAP1 (0.46) | RARGRARARARBEGFRERAP1 | |
| SCHEMBL8479737 | 0.67 | RARA (0.39) | RARGRARARARBEGFRERAP1 | |
| SCHEMBL8480277 | 0.67 | ERAP1 (0.40) | RARGRARARARBEGFRERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914406-A | ENZYME INHIBITOR; USEFUL FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMAN-LA ROCHE INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5750706-A | TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |