Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476991 | 0.81 | FFAR4 (0.33) | — | |
| SCHEMBL8130484 | 0.80 | TUBB1 (0.33) | KMT2AALDH1A1SMN1; SMN2KDM4EHIF1A | |
| SCHEMBL4741957 | 0.73 | ALDH1A1 (0.44) | KMT2APPARGALDH1A1 | |
| SCHEMBL31246170 | 0.72 | GAA (0.50) | MRGPRX4PTPN11KMT2AALDH1A1NPC1 | |
| SCHEMBL2497072 | 0.72 | HTT (0.44) | KMT2AALDH1A1POLBSMN1; SMN2KDM4E | |
| SCHEMBL6818430 | 0.71 | FOLH1 (0.61) | FOLH1MRGPRX4ALDH1A1POLBKDM4E | |
| SCHEMBL4741394 | 0.71 | FOLH1 (0.46) | FOLH1MRGPRX4KMT2AALDH1A1RAB9A | |
| SCHEMBL18887956 | 0.71 | ALDH1A1 (0.50) | KMT2AALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL30003143 | 0.71 | FOLH1 (0.49) | FOLH1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL12191687 | 0.71 | ALDH1A1 (0.45) | KMT2ADRD2ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914406-A | ENZYME INHIBITOR; USEFUL FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMAN-LA ROCHE INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5750706-A | TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5583222-A | ANTIINFLAMMATORY AGENTS FOR TREATMENT OF SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |