Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481664 | 0.78 | LMNA (0.56) | LMNARAB9APDE3BPDE3AHRH3 | |
| SCHEMBL9659827 | 0.77 | PDE3B (0.58) | LMNARAB9APDE3BPDE3AHRH3 | |
| SCHEMBL7277682 | 0.74 | LMNA (0.78) | LMNARAB9APDE3BPDE3AKDM4E | |
| SCHEMBL28802880 | 0.74 | LMNA (1.00) | LMNARAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7264498 | 0.74 | PDE3B (0.58) | LMNARAB9APDE3BPDE3AHRH3 | |
| SCHEMBL1754736 | 0.73 | GPR119 (0.61) | LMNARAB9APDE3BPDE3AHRH3 | |
| SCHEMBL11400199 | 0.73 | MAPT (0.57) | LMNARAB9APDE3BPDE3AHRH3 | |
| SCHEMBL7272078 | 0.73 | PDE3B (0.64) | LMNARAB9APDE3BPDE3AHRH3 | |
| SCHEMBL16351874 | 0.71 | CA1 (0.73) | LMNARAB9AKDM4ECA12CA1 | |
| SCHEMBL1965326 | 0.71 | CA1 (0.73) | LMNARAB9AKDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883090-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-03-16 | — | — | US | disclosed |