Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8663001 | 0.88 | MEN1 (0.58) | MEN1KMT2AGAAPOLBSMN1; SMN2 | |
| SCHEMBL8476134 | 0.84 | KMT2A (0.75) | MEN1KMT2AGAAPOLBCRHBP | |
| SCHEMBL8478361 | 0.82 | MEN1 (0.61) | MEN1KMT2AGAAPOLBCRHBP | |
| SCHEMBL8475825 | 0.82 | POLB (0.47) | MEN1KMT2AGAAPOLBCRHBP | |
| SCHEMBL8664639 | 0.81 | MEN1 (0.52) | MEN1KMT2AGAAPOLBP2RX7 | |
| SCHEMBL8475120 | 0.79 | MEN1 (0.52) | MEN1KMT2AGAAPOLBSMN1; SMN2 | |
| SCHEMBL8584049 | 0.77 | KMT2A (0.61) | MEN1KMT2AGAAPOLBCRHBP | |
| SCHEMBL8479289 | 0.75 | KMT2A (0.70) | MEN1KMT2AGAAPOLBSMN1; SMN2 | |
| SCHEMBL9013865 | 0.74 | POLB (0.46) | MEN1KMT2AGAAPOLBP2RX7 | |
| SCHEMBL8475812 | 0.72 | DPP4 (0.50) | MEN1KMT2AGAAPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861517-A | INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEINS LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-01-19 | — | — | US | claimed |
| EP-0876355-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | claimed |
| WO-1997019932-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | claimed |
| US-5861517-A | INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEINS LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-01-19 | — | — | US | disclosed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |