Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8475825 | 0.89 | POLB (0.47) | DPP4NR1H2NR1H3ANPEPPOLB | |
| SCHEMBL8476770 | 0.83 | FAAH (0.53) | DPP4NR1H2NR1H3POLBMEN1 | |
| SCHEMBL9013878 | 0.83 | DPP4 (0.49) | DPP4NR1H2NR1H3ANPEPMEN1 | |
| SCHEMBL8479960 | 0.81 | KMT2A (0.48) | DPP4NR1H2NR1H3ANPEPMEN1 | |
| SCHEMBL8663001 | 0.79 | MEN1 (0.58) | DPP4ANPEPPOLBMEN1KMT2A | |
| SCHEMBL9013865 | 0.78 | POLB (0.46) | POLBMEN1KMT2AGAACYP3A4 | |
| SCHEMBL9612014 | 0.76 | DPP4 (0.63) | DPP4NR1H2NR1H3ANPEPFAAH | |
| SCHEMBL8476116 | 0.74 | KMT2A (0.54) | DPP4NR1H2NR1H3ANPEPMEN1 | |
| SCHEMBL8664639 | 0.73 | MEN1 (0.52) | POLBMEN1KMT2AGAAP2RX7 | |
| SCHEMBL8480499 | 0.72 | MEN1 (0.65) | DPP4ANPEPPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861517-A | INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEINS LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-01-19 | — | — | US | disclosed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |