Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 13/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 10/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012357 | 1.00 | TOP1 (0.46) | TOP1KMT2ATOP2ATOP2BPRKD3 | |
| SCHEMBL7008071 | 0.93 | CYP3A4 (0.41) | TOP1KMT2ATOP2ATOP2BGSK3B | |
| SCHEMBL7006724 | 0.90 | KCNH2 (0.51) | TOP1KMT2ATOP2ATOP2BPRKD3 | |
| SCHEMBL8478990 | 0.90 | KCNH2 (0.51) | TOP1KMT2ATOP2ATOP2BPRKD3 | |
| SCHEMBL7009374 | 0.85 | TOP1 (0.59) | TOP1KMT2ATOP2ATOP2BPRKD3 | |
| SCHEMBL8482062 | 0.85 | TOP1 (0.59) | TOP1KMT2ATOP2ATOP2BPRKD3 | |
| SCHEMBL7011812 | 0.83 | KCNH2 (0.47) | TOP1KMT2ATOP2ATOP2BGSK3B | |
| SCHEMBL7007324 | 0.81 | STAT3 (0.42) | TOP1KMT2ATOP2AGSK3BALDH1A1 | |
| SCHEMBL8478277 | 0.80 | TOP2A (0.53) | TOP1KMT2ATOP2ATOP2BALDH1A1 | |
| SCHEMBL7011332 | 0.80 | TOP2A (0.53) | TOP1KMT2ATOP2ATOP2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5910498-A | NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1999-06-08 | — | — | US | disclosed |